Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37.We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated show-blouse-garnet by the Cdc37-Hsp90 system.Like other Hsp90 kinase clients, binding of CDK4/6 to Cdc37 is blocked by ATP-competitive inhibitor
Experimental studies were performed for crude oil-based fuel samples.The initial temperature of the samples varied down to 120 K.Ignition was performed by single metal particles of various shapes and temperatures, which reached 1350 K.A Doors specially developed experimental setup allowed recording of the proceeding processes at a high speed.As a r
We report on the effects of transverse spatial misalignment on the performance and stability of x-ray free electron laser oscillators Kimberwick (XFELOs).For this study, we adopt the FEL driven paraxial resonator model in which the transverse profile of the radiation field is represented by Gauss-Hermite mode expansion.Then, we apply Gaussian optic
Aim of review.To analyze the update to in the Walking Poles Rome-IV criteria for the functional heartburn and reflux hypersensitivity syndrome in comparison to the Rome-III criteria.Summary.The definition of functional heartburn in the Rome-IV criteria is updated by the statement according to which absence of response to the proton pump inhibitor t
Within the complicated and controversial taxonomy of cosmopolitan genus Salvia L.(Lamiaceae) are valuable species Salvia officinalis L.and Salvia sclarea L., which are important for the pharmaceutical, ornamental horticulture, food, and perfume industries.Genome organization and chromosome structure of these essential oil species remain insufficien